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GLP-1 administration modulates the phosphorylation state of calcium cycling proteins in the sinus node We speculated that the increased heart rate may result from phosphorylation changes elicited in the pacemaker cells expressing GLP-1R
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Instead of titrating to the full doses recommended for obesity treatment (e.g., semaglutide 2.4 mg weekly or tirzepatide up to 15 mg), microdosing involves starting and staying at much lower doses —sometimes as low as 0.1 to 0.25 mg per week for semaglutide or even intermittent use
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